# Therapeutic Alliance Research

February 27, 2024

Explore the latest research supporting the importance of the therapeutic alliance in Psychedelic-Assisted Psychotherapy:

2022 | [Therapeutic Alliance and Rapport Modulate Responses to Psilocybin Assisted Therapy for Depression](https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.788155/full)

2021 | [MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study](https://www.nature.com/articles/s41591-021-01336-3?error=cookies_not_supported&code=6c3ffc7d-5583-49ea-9176-94ae11247c55 "Access the article on Nature's website")

2020 | [Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder](https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2772630 "Access the full article on JAMA Psychiatry")

2020 | [Therapeutic alliance as a mediator of change: A systematic review and evaluation of research](https://www.sciencedirect.com/science/article/abs/pii/S0272735820301094)

2019 | [Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy](https://pubmed.ncbi.nlm.nih.gov/30917760/)